Two questions, not one
Causation in litigation is usually two questions, not one. General causation asks whether the exposure is capable of causing the disease in humans. Specific causation asks whether it caused the disease in this person. Renovatio Genomics evaluates both, drawing on the genomic data we generate and on the published literature, regulatory record, and toxicological evidence relevant to the exposure.
Method
General causation framed against a Bradford Hill assessment, with the genomic evidence integrated with the epidemiological and toxicological record.
Specific causation framed as a differential genetic etiology that considers, rather than dismisses, alternative causes. If the data support an alternative, the report says so.
Genomic findings (mutational signatures, predisposing variants, expression and methylation changes) are interpreted alongside exposure history, latency, and disease subtype.
Where the literature does not support a defensible inference at the level required, the report identifies that gap rather than closing it.
What we will and will not do
We will reach a defensible scientific opinion based on the data available.
We will not extend an opinion beyond what the data and literature support.
If the science does not support the proposed inference, the report will state that with the same clarity it would state a positive finding.
Reporting
Reports are written to be read by counsel and survived by deposing counsel. Each report contains a summary opinion, the underlying analysis, the methods, the data underlying the analysis, the alternative explanations considered, the limitations of the inference, and the references relied on.
